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Portfolio (Quarterly) Guide ↗

RTW INVESTMENTS, LP

· CIK 0001493215
13F Portfolio $10.0B AUM 88 positions Filed May 15, 2026 EDGAR ↗ ← All Funds
Q1 2026 Q4 2025 · All 9 New 25 Added 12 Reduced 12 Exited
Page 2 of 5  ·  88 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
21 APLS APELLIS PHARMACEUTICALS INC Healthcare 3,685,045.0 $148.2M 1.48% -4.0M -51.9% $40.23 +2.0%
22 IMCR IMMUNOCORE HLDGS PLC Healthcare 4,869,798.0 $146.8M 1.46% $30.15 -4.6%
23 RGEN REPLIGEN CORP Healthcare 1,206,000.0 $142.1M 1.41% +142K +13.3% $117.82 -12.3%
24 NBIX NEUROCRINE BIOSCIENCES INC Healthcare 1,062,072.0 $139.9M 1.39% $131.74 +20.7%
25 GH GUARDANT HEALTH INC Healthcare 1,481,033.0 $136.8M 1.36% $92.37 +6.8%
26 IMTX IMMATICS N.V Healthcare 12,869,340.0 $126.6M 1.26% +1.4M +12.6% $9.84 +13.5%
27 ZLAB ZAI LAB LTD Healthcare 6,574,032.0 $123.7M 1.23% -385K -5.5% $18.81 +8.1%
28 BLTE BELITE BIO INC Healthcare 715,332.0 $114.1M 1.14% $159.44 -10.3%
29 ISRG INTUITIVE SURGICAL INC Healthcare 220,000.0 $101.4M 1.01% +119K +117.3% $460.99 -7.1%
30 ORKA ORUKA THERAPEUTICS INC Healthcare 2,058,148.0 $101.0M 1.00% $49.05 +30.3%
31 GHRS GH RESEARCH PLC Healthcare 5,933,815.0 $83.4M 0.83% $14.06 +58.0%
32 XNCR XENCOR INC Healthcare 6,777,461.0 $81.7M 0.81% $12.06 -1.5%
33 URGN UROGEN PHARMA LTD Healthcare 4,543,895.0 $81.7M 0.81% $17.98 +65.1%
34 CNTA CENTESSA PHARMACEUTICALS PLC Healthcare 2,054,175.0 $81.6M 0.81% +263K +14.7% $39.72 -0.3%
35 IMVT IMMUNOVANT INC Healthcare 3,177,849.0 $78.9M 0.79% $24.84 +16.6%
36 RARE ULTRAGENYX PHARMACEUTICAL IN Healthcare 3,648,795.0 $76.4M 0.76% +649K +21.6% $20.95 +23.2%
37 HNGE HINGE HEALTH INC Healthcare 1,930,000.0 $74.4M 0.74% +1.6M +446.0% $38.56 +39.7%
38 CSTL CASTLE BIOSCIENCES INC Healthcare 2,758,335.0 $67.7M 0.67% +643K +30.4% $24.55 -23.1%
39 RCKT ROCKET PHARMACEUTICALS INC Healthcare 17,687,772.0 $63.3M 0.63% $3.58 -5.0%
40 TSHA TAYSHA GENE THERAPIES INC Healthcare 13,680,248.0 $61.2M 0.61% -2.7M -16.6% $4.47 +40.9%
Page 2 of 5  ·  88 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 99.6%
Technology 0.4%