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Portfolio (Quarterly) Guide ↗

RTW INVESTMENTS, LP

· CIK 0001493215
13F Portfolio $10.0B AUM Filed Feb 17, 2026 EDGAR ↗ ← All Funds
Q1 2026 Q4 2025 · All 91 New
Page 1 of 5  ·  91 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
1 MDGL MADRIGAL PHARMACEUTICALS INC Healthcare 1,993,687.0 $1.16B 11.63% NEW $582.34 -12.3%
2 INSM INSMED INC Healthcare 4,842,879.0 $842.9M 8.44% NEW $174.04 -39.2%
3 PTCT PTC THERAPEUTICS INC Healthcare 7,746,415.0 $588.4M 5.89% NEW $75.96 -7.7%
4 ARGX ARGENX SE Healthcare 673,497.0 $566.4M 5.67% NEW $840.95 -6.7%
5 PTGX PROTAGONIST THERAPEUTICS INC Healthcare 5,059,053.0 $441.9M 4.43% NEW $87.34 +16.6%
6 NTRA NATERA INC Healthcare 1,500,000.0 $343.6M 3.44% NEW $229.09 -14.9%
7 RDNT RADNET INC Healthcare 3,938,500.0 $281.0M 2.81% NEW $71.35 -24.6%
8 TARS TARSUS PHARMACEUTICALS INC Healthcare 3,335,320.0 $273.1M 2.74% NEW $81.88 -22.4%
9 COGT COGENT BIOSCIENCES INC Healthcare 7,592,241.0 $269.7M 2.70% NEW $35.52 -10.6%
10 PEN PENUMBRA INC Healthcare 866,499.0 $269.4M 2.70% NEW $310.91 +4.6%
11 IRTC IRHYTHM TECHNOLOGIES INC Healthcare 1,181,990.0 $209.7M 2.10% NEW $177.44 -37.6%
12 APOGEE THERAPEUTICS INC 2,712,097.0 $204.7M 2.05% NEW $75.48
13 APLS APELLIS PHARMACEUTICALS INC Healthcare 7,666,764.0 $192.6M 1.93% NEW $25.12 +63.3%
14 ACAD ACADIA PHARMACEUTICALS INC Healthcare 7,144,524.0 $190.8M 1.91% NEW $26.71 -21.7%
15 ESTA ESTABLISHMENT LABS HLDGS INC Healthcare 2,588,831.0 $188.7M 1.89% NEW $72.88 -9.8%
16 STOK STOKE THERAPEUTICS INC Healthcare 5,546,856.0 $176.1M 1.76% NEW $31.74 -7.8%
17 RGEN REPLIGEN CORP Healthcare 1,064,000.0 $174.3M 1.75% NEW $163.86 -36.0%
18 CYTK CYTOKINETICS INC Healthcare 2,721,158.0 $172.9M 1.73% NEW $63.54 +19.6%
19 IMCR IMMUNOCORE HLDGS PLC Healthcare 4,869,798.0 $169.0M 1.69% NEW $34.71 -18.5%
20 AXSM AXSOME THERAPEUTICS INC Healthcare 888,001.0 $162.2M 1.62% NEW $182.64 +24.3%
Page 1 of 5  ·  91 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 100.0%