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Portfolio (Quarterly) Guide ↗

TWO SIGMA INVESTMENTS, LP

· CIK 0001179392
13F Portfolio $123.9B AUM 4,546 positions Filed May 15, 2026 EDGAR ↗ ← All Funds
Q1 2026 Q4 2025 · All 1074 New 2043 Added 1209 Reduced 569 Exited
Page 216 of 228  ·  4,546 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
4301 KLRS KALARIS THERAPEUTICS INC Healthcare 30,650.0 $177K +3K +10.4% $5.77 -19.8%
4302 COHN COHEN & CO INC NEW Financial Services 11,711.0 $177K NEW $15.09 -25.5%
4303 YALA YALLA GROUP LTD Technology 28,200.0 $176K NEW $6.23 +5.3%
4304 CMPX COMPASS THERAPEUTICS INC Healthcare 33,100.0 $175K NEW $5.29 -66.2%
4305 DSGN DESIGN THERAPEUTICS INC Healthcare 16,300.0 $173K -30K -64.8% $10.64 -0.0%
4306 PLAY CALL DAVE & BUSTERS ENTMT INC Communication Services 16,000.0 $173K NEW $10.83 -6.5%
4307 CAG PUT CONAGRA BRANDS INC Consumer Defensive 11,000.0 $173K NEW $15.72 -12.1%
4308 TGEN TECOGEN INC NEW Industrials 67,418.0 $173K -151K -69.2% $2.56 +123.1%
4309 ALIGOS THERAPEUTICS INC 23,093.0 $172K -58K -71.4% $7.43
4310 CBUS CIBUS INC Healthcare 86,206.0 $171K +43K +97.4% $1.98 -38.4%
4311 IFRX INFLARX NV Healthcare 189,075.0 $169K -217K -53.5% $0.89 +167.7%
4312 OSUR ORASURE TECHNOLOGIES INC Healthcare 56,100.0 $168K NEW $3.00 -0.7%
4313 VTEX VTEX Technology 41,700.0 $167K NEW $4.00 -10.9%
4314 MCRB SERES THERAPEUTICS INC Healthcare 18,794.0 $167K -7K -27.0% $8.87 -13.1%
4315 IMMR IMMERSION CORP Technology 30,131.0 $165K NEW $5.46 +11.2%
4316 PTRN PATTERN GROUP INC Technology 13,149.0 $163K $12.43 +42.5%
4317 ZVIA ZEVIA PBC Consumer Defensive 138,500.0 $162K -543K -79.7% $1.17 +19.2%
4318 VMET VERSAMET ROYALTIES CORP Financial Services 17,000.0 $162K NEW $9.51 +17.5%
4319 NREF NEXPOINT REAL ESTATE FIN INC Real Estate 11,991.0 $162K -23K -65.5% $13.47 +11.9%
4320 HBAN PUT HUNTINGTON BANCSHARES INC Financial Services 10,300.0 $161K NEW $15.65 -1.7%
Page 216 of 228  ·  4,546 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Technology 21.8%
Financial Services 15.2%
Healthcare 13.2%
Industrials 13.1%
Consumer Cyclical 11.6%
Energy 5.2%
Basic Materials 5.1%
Consumer Defensive 4.6%
Communication Services 4.0%
Real Estate 3.7%