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Portfolio (Quarterly) Guide ↗

Siren, L.L.C.

· CIK 0002005245
13F Portfolio $4.9B AUM 119 positions Filed Aug 13, 2026 EDGAR ↗ ← All Funds
Q2 2026 · All 117 New
Page 1 of 6  ·  117 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
1 SRRK Scholar Rock Holding Corp Healthcare 9,575,013.0 $526.6M 10.66% NEW $55.00 -5.4%
2 KYMR Kymera Therapeutics Inc Healthcare 2,935,830.0 $336.7M 6.81% NEW $114.67 +5.9%
3 ERAS Erasca Inc Healthcare 11,397,781.0 $208.8M 4.23% NEW $18.32 -0.2%
4 MANE Veradermics Inc Healthcare 1,655,374.0 $203.5M 4.12% NEW $122.94 -12.0%
5 TNGX Tango Therapeutics Inc Healthcare 6,179,364.0 $193.2M 3.91% NEW $31.26 -19.1%
6 RVMD Revolution Medicines Inc Healthcare 900,000.0 $168.6M 3.41% NEW $187.28 +13.2%
7 BCAX Bicara Therapeutics Inc Healthcare 5,602,970.0 $166.4M 3.37% NEW $29.69 -16.0%
8 ARWR Arrowhead Pharmaceuticals Inc Healthcare 1,715,476.0 $139.8M 2.83% NEW $81.51 +8.8%
9 BeOne Medicines AG 465,000.0 $132.5M 2.68% NEW $284.97
10 EWTX Edgewise Therapeutics Inc Healthcare 3,184,629.0 $129.4M 2.62% NEW $40.63 +8.4%
11 RYTM Rhythm Pharmaceuticals Inc Healthcare 1,136,275.0 $126.2M 2.55% NEW $111.03 +4.0%
12 LXRX Lexicon Pharmaceuticals Inc Healthcare 44,303,518.0 $106.3M 2.15% NEW $2.40 -2.5%
13 ELVN Enliven Therapeutics Inc Healthcare 1,774,411.0 $90.1M 1.82% NEW $50.75 +17.3%
14 SYRE Spyre Therapeutics Inc Healthcare 968,598.0 $86.0M 1.74% NEW $88.78 +17.8%
15 Parabilis Medicines Inc 2,992,259.0 $81.9M 1.66% NEW $27.37
16 XENE Xenon Pharmaceuticals Inc Healthcare 1,318,564.0 $79.6M 1.61% NEW $60.36 +3.3%
17 Solid Biosciences Inc 7,690,405.0 $76.8M 1.55% NEW $9.99
18 ABVX Abivax SA Healthcare 576,000.0 $76.8M 1.55% NEW $133.26 -9.4%
19 COAG Hemab Therapeutics Holdings Inc 2,086,834.0 $76.6M 1.55% NEW $36.73 +45.9%
20 RCUS Arcus Biosciences Inc Healthcare 2,420,430.0 $74.6M 1.51% NEW $30.83 -4.1%
Page 1 of 6  ·  117 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 92.4%
Technology 3.9%
Communication Services 1.8%
Financial Services 1.3%
Consumer Cyclical 0.6%
Real Estate 0.0%